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Because of an unexpectedly high rate of worsening,we report the results of treatment of Guillain-Barre syndrome with a standard regimen of human immune globulin(HIG)in 15 consecutive patients.Patients were treated with 1.5 g/kg HIG for 4 days beginning a mean of 7 days after the first symptoms.Eight stabilized or improved but seven deteriorated during or within the first 5 days after treatment,and four remained ventilator- dependent for at least 2.5 months.One had a severe relapse 5 weeks after treatment.Five patients subsequently received plasma exchange and two improved.Our experience varies from previous reports that have endorsed HIG treatment for Guillain-Barre syndrome. |
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